Little one: Welcome to my Mommy’s podcast.
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Katie: Good day and welcome to “The Wellness Mama Podcast.” I’m Katie from wellnessmama.com and wellnesse.com, that’s wellness with an E on the top. And I’m right here at this time with my pal, Naveen, who’s an intensely curious entrepreneur who has been taking over some huge, audacious concepts to push humanity ahead. He’s the writer of the award-winning ebook “Moonshots: Making a World of Abundance,” and his present moonshot adventures are Viome and Moon Specific, which is an area firm. However as a serial entrepreneur, he’s additionally based InfoSpace, Intelius, and Expertise Sensible, amongst others.
And his present work is in Viome Life Sciences, which was based in 2016 with a mission of creating sickness elective by predicting and stopping persistent illness by a deeper understanding of a person’s biology at a molecular stage. And it’s constructed on an AI-driven platform that analyzes the interplay between meals, our microbiome, and our human selves to develop precision suggestions to stop and reverse persistent illness. He’s additionally the vice-chairman of the board at Singularity College, and on the board of XPRIZE Basis. He’s been the recipient of many issues together with Entrepreneur of the Yr, Most Inventive Individual by Quick Firm, High 20 Entrepreneurs, and plenty of extra.
On this episode, we speak concerning the human ecosystem and customized optimization of your intestine well being and your general well being. We speak concerning the motive the intestine impacts the whole physique. Why it’s not simply genetics from our mother and father however really our ecosystem inside our intestine that controls our physique. Why 70% of the immune system is within the intestine. How microbiome steadiness begins at beginning and even earlier than. How 90% of serotonin is produced within the intestine, not the mind. What makes up the ecosystem of the intestine. We get fairly granular on this one.
The distinction between DNA and gene expression. How some meals could be good for some folks and never others, and know which is greatest for you, but additionally, the universally dangerous meals. Why there are some universality unhealthy ones however not universally good ones. Why he doesn’t advocate harsh merchandise that kill micro organism within the mouth or within the intestine. The true motive it’s vital to chew your meals rather well earlier than swallowing, and a lot extra. Lot’s of sensible information on this episode. Additionally, a number of hyperlinks to be taught extra within the present notes at wellnessmama.fm, so test these out. However with out additional ado, let’s be a part of Naveen Jain. Naveen, welcome again.
Naveen: Properly, Katie, so good to see you lastly after a protracted, very long time.
Katie: I’m so excited we get to have a dialog and get to report it and share it at this time, and we’re gonna speak quite a bit about intestine well being and even past intestine well being, how this impacts the well being of the entire physique. Earlier than we do, although, I’d say you’re the one individual I do know in actual life who has a Moon rock assortment. And so, I’d love so that you can simply speak about this as a result of I feel you’re my solely hobbyist Moon rock collector.
Naveen: Properly, I feel, Katie, you already know, to me, the Moon is symbolic. It’s symbolic of what humanity is able to doing. So, to me, going to the Moon is a approach of expressing that there’s nothing that’s unattainable for us to do. Though it’s known as “Moonshots” that individuals thought was tough, if not unattainable to do and having, you already know, now to have the ability to go to the Moon and to me, the gathering of area rocks really was simply merely a passion of capable of maintain one thing in your hand. Which may be even earlier than the beginning of our planet. And it provides you some concept of how fragile we’re that if we don’t handle ourselves, our planet, we as humanity might not survive. As a species, we might not survive.
So, you already know, concept of when somebody says, “I’m actually apprehensive about our planet,” ask the planet and planet will let you know, “Don’t you are concerned about me as a result of we…” Planet will just do wonderful however human species might not survive. Similar to dinosaurs. And to me, having a Moon rock merely jogs my memory that all of us are related collectively. When one thing exterior us goes improper, we as inner ecosystem may also be impacted, proper. And that’s coming all the way down to, you already know, should you have a look at what’s above, so beneath is admittedly what’s exterior the ecosystem and the universe impacts us, and our ecosystem inside us impacts the universe.
Katie: I really like that you just stated it like that as a result of I interviewed my oldest son on this podcast a pair hundred episodes in the past when he launched a cookbook and you already know him as properly. And I requested him that query. You understand, your era’s gonna face quite a bit within the environmental and local weather stuff. And, I raised this query and he goes, “Properly, mother, you’re really asking the improper query as a result of the…”
Naveen: Oh, I find it irresistible, I find it irresistible.
Katie: He stated, “The planet is a self-correcting organism. It’s gonna heal itself. It’s only a query of whether or not we get to remain right here when it does. And we should be asking how we could be extra synergistic inside an atmosphere that’s greater than us.”
Naveen: That’s the good reply. That’s precisely how I’d see it that…you already know, when folks say, “Aren’t you apprehensive concerning the planet?” I say, “That’s not the query try to be asking.” It’s, “Are we apprehensive concerning the human species?” That’s what we needs to be asking.
Katie: Which is an ideal segue as a result of that’s one thing that you’re intimately concerned with and I’d say not apprehensive about however working to unravel. My listeners are fairly well being savvy and perceive or at the least have a passing understanding that intestine well being impacts the entire complete physique. However I really feel like this idea is…properly, we’ve recognized points of it for a very long time. We’re seeing a lot extra analysis about it proper now. And we’re…due to firms like Viome, we’ve many extra tangible instruments to really perceive and begin to do one thing about that. However to begin broad, sort of give us an summary of what we imply by the well being of the intestine impacts the well being of the entire physique.
Naveen: So, properly, to start with, you already know, let’s simply begin from the start. We as human beings should not merely a product of the DNA from our mother and pop. What we’re is a symbiotic ecosystem, and in that ecosystem, 99% of all of the genes which can be really expressed in our human physique should not our personal. They arrive from these microbes which can be in our mouth, in our intestine, throughout us. So, think about…I imply, there’s actually…if we have a look at the human beings as such by way of all of the genes which can be expressed that makes us who we’re, they don’t seem to be people. They’re principally microbial. We’re dwelling of their world. They don’t stay in our world, proper.
So, once we perceive that, you already know, though you possibly can argue that they’re the puppet masters and we’re merely the host or puppet for his or her profit, and you possibly can argue sometime that possibly they really created us to unfold them round, possibly they created us to allow them to rule the world, proper, however in all honesty, we coevolved collectively. In coevolution what occurs is we feed them and we give them a pleasant and heat and cozy place to remain. In flip, they feed us the vitamins that our physique wants to really be wholesome, proper. So, think about from the time a child is born, and I feel that is one thing that most individuals don’t notice, that within the first couple of days of mom’s breast milk is filled with oligosaccharides. And that can not be digested by the human physique. That’s there just for the microbes within the intestine to have the ability to convert into vitamins. Which means it’s to create the ecosystem inside us.
Now think about what nature is telling us, that we simply created a offspring and one of the simplest ways to maintain this offspring wholesome is to not feed it however to feed them who’re going to maintain the offspring wholesome. And because the child goes by the beginning canal, that is the primary publicity the newborn will get to the entire world of microbiome. It will get…fully inhales the microbiome because the child’s going by beginning canal. And sadly, among the moms for apparent causes find yourself getting a C-section. They really…the infants should not going by the identical…they’re uncovered to pores and skin microbiome relatively by the beginning canal, the microbiome that they might get by the beginning canal. And that could be a essentially…the newborn, when it’s born, is definitely…the character has created in a approach that the microbes get launched into the newborn on the time of the beginning and that really now turns into a coevolution course of. And the mom’s breast milk begins to feed these microbes to create this ecosystem.
And because the intestine microbiome begins to get wholesome, it begins to coach our immune system. And I feel that is the elemental half that individuals want to know. Seventy % of our immune system is alongside our intestine lining. In actual fact, all of the analysis exhibits that how intestine microbiome is continually coaching our immune system what’s a pal and what’s a foe, proper. So, in some sense, should you have a look at the human physique, there’s a tube that goes by us. There’s a high of the tube in your mouth after which there’s the underside of the tube, and you then begin to take a look at all alongside the traces there’s a huge quantity of microbial existence there. And so they actually are consistently interacting with our immune system and the immune system is now understanding when there’s really a pathogen that’s coming by the meals or the pathogen that’s coming by the skin world, react to it. And these microbes are the primary sign that tells the immune methods, “This isn’t good. Go do one thing about it, proper.”
And I feel to me, that symbiotic relationship breaks down when there’s a dysbiosis within the intestine. So, I feel as your son identified, not simply the planet however even the human physique is designed to heal itself. The human physique is designed to be in homeostasis. And any time…and whether or not we minimize our pores and skin or whether or not there’s some sort of pathogen or we get some sort of a illness, it usually is designed to heal itself if our physique is in steadiness. So, when there are intestine microbial actions and the human host are consistently in sync and wholesome and our immune system is wholesome, then our physique will really heal itself. When there’s a dysbiosis or imbalance of the intestine microbiome, that is the place the unease occurs. When your physique isn’t comfy, you get illness which we name illness.
Katie: Yeah, so many vital factors you simply stated to unpack. And I feel the primary being that we actually are extra bacterial than human and also you…right here you stated you’re what you eat nevertheless it goes to this point past that. It’s not even you’re what you eat and even you’re what you eat-eat, however what your intestine micro organism eats and the way it grows. And I really like that you just introduced up the beginning canal factor as a result of I’m a doula and I’ve really helped in a number of C-section births with feeding the newborn, as a result of such as you stated, should you don’t…the newborn is of course meant to seed their intestine by the beginning canal. And if that doesn’t occur, such as you stated, they’re seeding to the hospital room, to pores and skin, to probably disinfectants which can be in that room, all types of issues. And we all know that this intestine micro organism at beginning, an increasing number of we be taught, units you up to your entire life. But additionally, the excellent news is…and I do know that Viome does quite a lot of analysis on this. All isn’t misplaced should you don’t get an ideal begin. We now have the flexibility to sort of get a snapshot and look within the intestine in a extremely distinctive approach after which optimize to enhance somebody’s well being going ahead.
And likewise, such as you stated, the physique’s pure state is well being. It’s not usually that we have to do something drastic. We have to get out of our personal approach and simply take away the issues which can be protecting the physique from being wholesome or possibly generally give it little additional vitamins to assist get there. Speak slightly bit concerning the science of Viome and what we’re testing as a result of this expertise didn’t even exist a pair many years in the past, and now we’ve such wonderful information from this.
Naveen: Properly, it’s very fascinating is this concept of, you already know…should you return and have a look at couple of many years in the past, it was really the micro organism and all these organisms have been thought of as an enemy of the human physique. That’s the minute you see them, your job is to kill them as rapidly as attainable as a result of they will’t probably be there for our good, proper. And as we began to be taught extra concerning the human physique, we realized that the majority of those organisms are literally commensal. They’re alleged to be there and so they actually…once we feed them issues like, you already know…in olden days, once we have been dwelling within the savannas of Africa, we’ll pull out a leaf or we’ll pull out the basis and eat it. That’s filled with fiber. These fibers are literally what our intestine microbes eat, and people intestine microbes, by consuming these fibers, really flip them into brief chain fatty acids. Issues like butyric, issues like acetate, these have been all of the vitamins that our physique wanted.
In actual fact, should you begin to consider it, 90% of all of the serotonin is definitely produced in our intestine, not in our mind. So, should you actually take into consideration all of the issues which can be being achieved within the intestine and the way what occurs within the intestine doesn’t merely keep within the intestine, it really impacts the entire physique together with our mind to coming again to it, Katie, that you just identified. What occurs in our intestine impacts our temper. So, whether or not it’s a despair or nervousness or, you already know, you possibly can name them any names you need, you already know, a lot of this stuff together with autism is now related straight into the intestine microbiome. In actual fact, they’ve achieved now the analysis the place they did merely a microbial transplant known as a fecal transplant and so they have been capable of actually present that children with autism, their autistic signs went down by 50% even after two years simply by merely doing the microbial transplant. They have been capable of present once you took an individual that has a despair a microbial transplant or nervousness, it may be transferred just by transferring the microbiome into one other species. And so they’ve achieved them in mice and so they’ve achieved that actually in people, and clearly, it was achieved by mistake however that’s really the way it occurred.
In actual fact, what’s actually fascinating is habit. And so they’ve proven the identical factor. They took…there have been 17 folks on the analysis that have been fully hooked on alcohol. And people folks, they gave them a fecal transplant from individuals who really had no habit. And these folks’s habit went away. Now think about that, that our intestine microbiome are controlling our mind by way of what to do. That’s what the habit is, proper. And I feel that’s actually phenomenal.
And now what we’re studying is each sort of most cancers…actually what they’ve now checked out is each single strong tumor has microbes inside that tumor. Take into consideration {that a} second, the microbes are contained in the tumor. And what we discovered most fascinating was there’s microbial peptides being displayed on the floor of the tumor. Now, why would a tumor that’s an organism eager to survive would ever show a microbial peptide except it’s there to idiot our immune system into pondering that is self and protects the tumor towards the immune system attacking, proper?
Now, think about what…one other factor that’s most fascinating I discovered was once you do immunotherapy, it really works about one-third of the time. And the folks the place the immunotherapy doesn’t work, within the 70% of the folks that immunotherapy didn’t work, they merely have been capable of do a change of their intestine microbiome and the identical immunotherapy began working. So, our intestine microbiome isn’t solely there to maintain us wholesome from all of the illnesses at this time we name the totally different names. Coronary heart illnesses, it’s coming from our intestine microbes really producing issues like trimethylamine or TMA. TMA will get absorbed within the blood and our liver converts them into TMAO, trimethylamine oxide. In actual fact, we will now have a look at issues like LDL manufacturing which is a foul ldl cholesterol manufacturing and see how microbial actions and microbial metabolites really change the LDL manufacturing. You’re in a position to take a look at how…what’s occurring in your intestine, how are we altering the inflammatory markers in our host. So, we’re capable of measure the intestine exercise and the human host exercise, all their cytokines. So, we’re taking a look at each interleukins, we’re taking a look at all the inflammatory markers to see how they’re altering with the intestine microbial exercise.
And so, anyway, the purpose I’m making an attempt to make is that you just talked about one thing about these micro organism, and I simply need folks to know the microorganisms should not simply micro organism. They’re predominantly micro organism however additionally they encompass yeast, viruses and even the RNA viruses or fungus or mildew. All of this stuff are literally the entire ecosystem and the most important half actually should you observed virtually 10 to 1 if no more is definitely phages. And phages are the viruses that infect the micro organism. And should you have a look at any nature whether or not you’re trying within the swamp otherwise you’re trying on the intestine microbiome, actually there are 10 instances extra phages than the micro organism alone. And which means these viruses that infect micro organism are modifying the bacterial…the organism, the features of those micro organism that actually adjustments how these micro organism behave by way of what features they’re performing.
So once more, what’s actually fascinating is by taking a look at what organisms are there, won’t ever let you know what’s going on in your physique. In actual fact, their features are what makes the distinction. Which means what they’re producing can…is admittedly the one factor that issues what these intestine microbes are producing, not who they’re. And I feel, Katie, you most likely know that quite a lot of the folks like Akkermansia muciniphila. Among the firms are promoting them as a probiotic with out realizing that Akkermansia could be good for some folks and in reality it’s the primary motive for inflicting a number of sclerosis, and it has additionally been straight linked to Alzheimer’s, proper. So now give it some thought. The identical organism can do one thing good for one individual and may do one thing actually unhealthy in one other individual. So, taking one thing blindly, taking any complement, any probiotic, any prebiotic blindly is definitely not good for you as a result of your physique is totally totally different than different individual’s physique. The identical organism or similar probiotic could be good for somebody and might be dangerous for an additional individual. And that’s the most important studying we’ve had within the final six years.
Katie: Yeah, I really like that you just introduced up the fecal microbiota switch as properly. I’ve seen among the science on this and… you already know, caveat, this isn’t one thing to aim at house nevertheless it’s fairly wonderful what they’re engaging in in labs with some actually focused and really particular methods of doing that. And I really feel like in a way, that is additionally one thing you possibly can accomplish with out having to go to that excessive if you already know what you’re working with. And for the final two years, I’ve been saying, you already know, early on in well being and wellness, I’d discover out info, learn research and be so excited and write about it, and I’ve realized an increasing number of over the past 15 years every thing is so customized and so individualized. And so now when folks ask me like, “What precisely did you do to reverse your Hashimoto’s?” I say, “You understand, I can let you know what I did nevertheless it’s not gonna work the identical for you. It may be an concept with the start line nevertheless it’s not gonna be your blueprint. Every of our blueprints is gonna be very, very totally different.”
Which is why I really like now an increasing number of entry to those at-home testing whether or not or not it’s issues like Viome, even now blood testing accessible at house, genetic testing simply so we will have extra info and entry. And I’ve stated so many instances on right here we’re every our personal major healthcare supplier. On the finish of the day, it’s nice to work with docs however we’re every our personal major healthcare supplier. And I really feel like having instruments in our pocket that permit us be simpler at that may actually, actually make a distinction. So, let’s speak slightly bit extra concerning the personalization facet of this as a result of I additionally am curious…you already know, I do know you stated every thing is so totally different. What’s good for one individual may be not for an additional. Are there any issues which can be sort of universally unhealthy that you just’re discovering in Viome? Like, I’d put possibly processed vegetable oils on the don’t cross checklist, however I’m curious what you’re seeing within the information.
Naveen: Yeah. So to start with, it’s actually fascinating. I feel you phrased it appropriately. There isn’t any such factor as common wholesome meals. And which means there isn’t a such factor that’s good for everybody. Which means the identical meals could be good for you or unhealthy for somebody. Nonetheless, there are some common unhealthy issues that you would be able to know. So, there isn’t a common wholesome factor however there are universally unhealthy issues. Sugar is a type of unhealthy issues. There isn’t any one who says, “The sugar is nice for me, proper.” In order that’s really having a fried, you already know, fried meals. So, all fried stuff, it’s simply unhealthy for everybody. Consuming quite a lot of sugar, it’s simply unhealthy for everybody. Nonetheless, what we discover most fascinating is that analyzing the human physique and analyzing based mostly on what’s going on and what’s dynamically altering in your physique…and I feel quite a lot of the people who find themselves listening to it, I would like folks to know the distinction between a DNA which is static. So when folks do their DNA take a look at, it tells you what’s inherently there in your physique. It doesn’t let you know what is definitely happening in your physique. Which means…if, Katie, you enable me, I’m gonna clarify the DNA as a result of I feel to me lots of people get very confused about what DNA is.
So, each a part of our physique is an identical DNA. Which means you have a look at my hair, you have a look at my eyes, you have a look at my enamel, you have a look at my nails, you have a look at my finger, it’s precisely the identical DNA. Then why is it we don’t have the eyes rising on my fingers and the nails rising on my head? Identical DNA. And the reply is there’s…when some genes are overexpressed, some genes are below expressed, the identical DNA can turn out to be eye, similar DNA can turn out to be nail, similar DNA can turn out to be pores and skin, similar DNA can turn out to be coronary heart cells or neurons or issues like that, proper. So, level is DNA is like an alphabet and the story you’re writing is definitely what’s being expressed. It’s known as RNA. So, RNA tells you the story that’s being written for you proper now and DNA tells you each attainable factor that may occur. And that’s one factor.
So, what we do at Viome, Katie, is we have a look at your gene expression and what gene expression tells us is what story your intestine microbes are writing. What story your human host is writing. And now I’m gonna come again and let you know…some information to share with you in direction of the top. As soon as we perceive all that’s happening, we’re capable of then let you know, “Hey, don’t eat broccoli or cabbage as a result of your sulfide manufacturing in your intestine is simply too excessive and the sulfide want sulfates to supply sulfide and the broccoli and cabbage are very excessive in sulfate so you must minimize it down, proper.”
We are able to let you know that…lots of people will let you know go take vitamin B3. However vitamin B3’s really not good for you when you’ve excessive uric acid manufacturing. So don’t take vitamin B3 if in case you have excessive uric acid manufacturing. Equally, everybody will let you know, “Hey, take curcumin and turmeric. It’s actually good anti-inflammatory.” It’s. Nonetheless, when your bile acid manufacturing may be very excessive, you don’t wish to take curcumin as a result of it’s going to transform into bile salt that’s gonna trigger extra irritation. Lots of people assume one way or the other taking NAD or NR, and NMN which is precursor to NAD is definitely improve your longevity. It’s true for some folks it might try this, however for others it really will hurt you when you’ve excessive mobile senescence, or when you’ve excessive inflammatory exercise. You don’t wish to be taking extra NAD as a result of that’s gonna improve the mitochondrial biogenesis that’s going to extend extra free radicals, gonna improve excessive mobile senescence, proper.
So, the concept actually is that it’s a must to be taught what is going on earlier than you deal with your physique like a black field. And I feel you’ve stated it proper, that we’re simply…we’re the CEO of our personal well being. We’re those who must know what is going on in our physique as a result of our major care physician…I don’t find out about you, Katie. Once I go to my major care physician, by the point I begin talking, he’s already writing the prescription. I imply, actually, the phrase he says… “Oh, did you say coughing? Right here it’s. Did you say this? Give me the ailing, I’ll provide the capsule.” And that’s all they’re merely doing. They don’t must…they don’t care to know what’s inflicting that to occur in my physique. Like, you had Hashimoto, or should you had any sort of an autoimmune illness, the very first thing they let you know is simply take the immune suppression medication and suppress the symptom. Not fear about what’s inflicting it, and that could be a elementary downside that our healthcare system has is that our medical industrial advanced, everybody makes cash once we are sick and nobody makes cash once we are wholesome. And so, we determined to vary that. In my world of the longer term, Katie, we imagine that…I feel identical to you simply stated, the way forward for healthcare goes to be delivered at house, not on the hospitals.
And the medicines of the longer term are gonna come from a farm, not a pharmacy. And that’s going to be the most important change you’ll begin to see us taking management of our personal well being. And I feel COVID has been one of many…I’d say should you look again at COVID 10 years from now, it will likely be the most important inflection level that occurred in humanity’s notion of that we as people have management our personal actions and our actions have well being penalties.
Katie: Completely. I feel so many good silver linings and instructing moments in COVID and folks spent extra time at house and with their households cooking dinner at house. There have been quite a lot of nice outcomes, as exhausting because it was for many individuals. I feel we will concentrate on these positives. And I really like your rationalization of DNA and the way it goes past simply your genetics. It’s about how they’re expressed and the way that’s managed within the intestine. And I’d like to go slightly bit deeper about Viome as a result of I do know I talked to you years in the past about this and also you guys have made some huge advances since then. So, speak about sort of the snapshot of what Viome is testing after which how individuals are making adjustments based mostly on that and what they’re seeing.
Naveen: Sure. So clearly, Katie, a few years in the past we did a intestine intelligence chart that merely measured your intestine well being. After which we realized that that was actually good nevertheless it didn’t inform us how these intestine adjustments have been impacting us and the human physique. And so, we now launched…about two years in the past throughout COVID really, we launched our well being intelligence take a look at that measures your blood and it measures your stool, and by doing the finger prick blood, so that you don’t should go to a lab. It’s a easy finger prick blood, couple of drops of your blood. And your starch of your stool. We’re capable of now have a look at each your intestine well being and your human host and capable of now let you know what’s your organic age. And that tells you not solely, you already know, how properly or how poorly your physique is ageing in comparison with your chronological age.
So, to present you an concept, I’m now gonna be 63 in September and my organic age is all the way down to 50. And that tells you that actually that my physique is performing on the stage once I was 50. And I really feel it. I run up the steps two stairs at a time and I’ve extra power than actually I had once I was 50. And that merely tells you what your organic age is. Then we offer you immune well being. Which means how properly are you protected towards should you have been to catch flu or chilly or any sort of pathogen, how properly your physique is ready to defend itself? And that’s your immune well being. Your mobile well being. That tells you ways properly your cells are capable of endure the issues which can be happening within the human physique. Mitochondrial well being, that’s your power manufacturing unit. How properly the mitochondrial well being is performing as a result of if it’s not, you get mind fog, you’re feeling fatigued, you’re feeling drained. We offer you clearly your intestine well being.
And now that is one thing new that we’re gonna be launching in June and we’re launching a brand new product known as full physique intelligence. And for the primary time, we’re gonna be analyzing all the way in which from high of your tube, your saliva, your stool and blood, all three on the similar time. And by taking a look at that, we’re additionally gonna have the ability to present you some extra insights akin to your coronary heart and metabolic well being. We’re gonna be supplying you with your mind and cognitive well being. We’re gonna have the ability to present you your oral well being akin to your gum well being, your enamel well being and all of the gum, you already know…leaky gum as a substitute of simply leaky intestine. We’ll have the ability to present you ways properly your boundaries of your gums are performing in order that microbes should not going into your blood.
And different factor we do now which we didn’t do till a couple of yr in the past is once you do a take a look at, not solely you get your deep perception what’s occurring in your physique and never simply let you know listed here are the meals which can be good for you and right here is why. Listed below are the meals you must keep away from and why. We used to let you know listed here are the dietary supplements you must take. Now we transcend that, Katie. We’re capable of let you know you solely want 22 milligram of berberine day-after-day. You want 17 milligram of elderberry day-after-day. You want 79 milligram amylase day-after-day. And we undergo each vitamin, minerals, herbs, meals extracts, digestive enzymes, amino acids, probiotics, prebiotics, and we actually make these for you on demand.
There isn’t any premade stuff. Consider it like a compounding pharmacy. There are robotics compounding pharmacy. It says, these capsules are being made for Katie. Go to bin quantity 17, get 17 milligram of elderberry. Go to bin quantity 29, get 27 milligram of berberine. And we actually take all of the strawberry extract right here, put this factor right here. And by the way in which, as soon as we get the powder, we make the capsules and ship them off to you each month. And as your physique adjustments, we modify your dietary supplements on the similar time. So, each time you retest, we are saying, “Oh, you don’t want amylase anymore. What you really want is butyrate now,” proper. And we actually are capable of modify your…as your physique is altering, we adapt the diet that your physique wants. And people are the brand new issues that I’m tremendous enthusiastic about.
Different issues that I’m actually, actually enthusiastic about…and we’ve not talked to anybody but about it. We’re gonna be launching in June additionally our most cancers detect. And that is gonna…first time as a shopper you’ll have the ability to spit in a tube and with 95% specificity and 90% sensitivity, we’ll have the ability to let you know if in case you have any oral most cancers or throat most cancers. After which we’ll have the ability to really join you with a physician to have the ability to do one thing about it. So, in case you are above…over 50 years outdated or have any historical past of smoking, vaping, chewing tobacco, you’ll have the ability to really at house do a take a look at and really know that you just’re not at a danger of creating a most cancers proper now. Otherwise you’re creating a most cancers proper now.
Katie: Yeah. That is so leading edge and I feel simply to spotlight what you stated, that is actually fascinating information of mainly machine studying and AI and this adaptive expertise. And since you’ve now examined hundreds and hundreds, most likely a whole lot of hundreds of individuals, then the algorithm has entry to all this info so it may possibly proceed to get an increasing number of specialised and direct with the suggestions and be taught your personal physique over time. So, you’re getting this sort of ongoing, correct image which I feel is so fascinating.
Naveen: Yeah. So, Katie, we’ve analyzed over 350,000 samples already. And that has given us this…you already know, the a part of being the…a part of that Viome ecosystem is each single one that joins profit from the opposite 350,000 samples that we’ve analyzed and so they contribute to the ecosystem, and our AI and machine studying is continually getting higher. And for each single one that joins profit themselves and advantages the humanity on the similar time as a result of now the extra we be taught, the higher suggestions we will make for everybody. So, earlier than we simply solely might have a look at your stool. Now we have a look at stool plus blood. Now it’s stool plus blood plus saliva. And we’re gonna launch…the following factor shall be with urine. After which we’re gonna begin to take a look at different biomarkers in your physique. So, our suggestions get an increasing number of exact as we be taught an increasing number of concerning the human physique. And our actual hope is, you already know, in my lifetime we’ll have the ability to perceive what causes the onset of a persistent illness and what causes them to progress and to have the ability to stop them from occurring within the first place, to diagnose them early once they really do occur, and to provide you with a treatment for these illnesses. Not merely handle them however to treatment them as soon as for all for every particular person. And that’s going to be the last word objective of our life.
Katie: And I really like that you just introduced up the interplay of all of the totally different microbiomes throughout the physique as properly and the way you’re taking a look at all of those, as a result of a few of my early analysis was in oral well being and studying as an example that strep mutants and the micro organism that trigger gingivitis don’t each exist on the similar time. And it is because we’ve an oral microbiome. And if it will get out of steadiness in a single course or the opposite, you’re gonna find yourself with these issues. However the reply isn’t sterilizing your mouth and killing all micro organism identical to we wouldn’t wish to within the intestine. It’s getting a wholesome oral microbiome that has that ecosystem that it wants. Identical factor with the intestine. And such as you stated, you’re taking a look at these all through the entire physique. I do know your daughter’s additionally performing some fascinating analysis with the vaginal microbiome and I’m excited to talk along with her about that.
However I feel, like we talked about to start with, since our physique is extra bacterial than human, the extra we perceive about these interactions, the extra sort of intricate information we will get to make enhancements over time and naturally there could be a most cancers connection right here. You understand, I’ve heard it stated that most cancers is a metabolic illness in some half. And this can be a approach of…as a result of even inside a person, should you’re taking a look at a metabolic illness, you’re taking a look at, “Okay, we have to get blood sugar in test. We have to get blood stress in test. We have to get weight problems measures in test.” However the way in which to try this’s gonna be totally different for each single individual.
Naveen: I feel it’s a metabolic and inflammatory illness. So, I imply, it’s induced…persistent irritation is a root reason for persistent illnesses. Nonetheless, what causes the irritation in our physique is totally different for every particular person. So though it’s the irritation which may be on the root trigger however the underlying causes for that irritation are very, very totally different. And as you talked about, our daughter is, you already know…has this firm known as Evvy, E-V-V-Y, which appears on the vaginal microbiome. And to me, what she’s doing is so phenomenal and particularly your viewers, each single girl ought to try this as a result of that’s actually…goes to be…you already know, a number of ladies undergo by most of the illnesses that we as males would by no means perceive. And that to some extent is, you already know, largely reproductive organ and most of the instances the later analysis exhibits that vaginal microbiome is concerned in preterm beginning, within the well being of the newborn and all of the issues that you just talked about because the child goes by the beginning canal. All of the issues that come out actually are contributory from the vaginal microbiome. So, my excessive advice…once more, I’m biased. I feel each girl needs to be doing the Evvy take a look at, proper.
Now, coming again to the stuff you talked about that, you already know, human well being is advanced however as soon as we perceive biochemical stage what’s going on, that’s the rationale as a substitute of taking a look at organisms and as a substitute of taking a look at DNA, we targeted on the gene expression or RNA. We targeted on what microbes are producing. Wanting on the entire physique. And I feel, Katie, I wanna level out that the merchandise that you just construct for oral well being are among the greatest merchandise as a result of, to me, what’s the largest gamechanger is folks thought the organisms have been your enemy. So, they’ve this Listerine. Kills 99% of all of the micro organism in your mouth. For heaven’s sake, don’t try this. While you kill the ecosystem in your mouth, it really destroys the entire digestive tract. And I wanna simply emphasize, you already know, to folks when our moms informed us to chew our meals, she didn’t ask us to chew the meals as a result of they thought the meals was too huge to go down our esophagus, proper. It was really was once you chew your meals, you’re permitting the oral microbiome in your saliva to really predigest the meals, and by predigesting the meals…along with predigesting, it additionally sends the sign to the intestine and to the physique about what’s coming down. So, when it tastes candy, it begins to launch the sign for pancreas to launch the insulin, as a result of it is aware of the candy stuff is coming down.
So, the principle factor is that we have to enable the oral microbiome to predigest the feed so your small gut can now soak up the vitamins which can be already predigested. So, if you end up…so two issues it’s essential take into consideration right here. And one is if you end up confused and you’re consuming your meals, it doesn’t get correctly digested and right here is why. If you find yourself confused, you’re in a combat or flight response. And the primary factor that occurs once you’re in combat or flight response is your digestive system shuts down. Bear in mind why it was designed. While you’re operating away from a tiger, at the moment, the physique knew there isn’t a level worrying about digesting your meals as a result of both you’re gonna be lunch for another person otherwise you’re going to outlive. And should you turned lunch for another person, it didn’t matter. And should you survive, guess what? The stress went down and also you moved from sympathetic mode to parasympathetic mode and you possibly can digest your meals.
While you come from work and you’re confused, what can we inform folks? Earlier than you eat, do the gratitude. Why is that? It’s since you wish to deliver your physique from sympathetic mode into parasympathetic mode. Do away with combat or flight response. By taking the deep breath, by doing the gratitude, what you’re doing is definitely permitting your physique to have the ability to be able to digest the meals. Then once you chew your meals, you’re permitting your saliva and oral microbiome to really predigest your meals. And these are easy methods we realized within the historical tradition however we now know scientifically why did they are saying that, proper. We inform…like, Katie, it’s possible you’ll not know that my mother and pop and our faith, they don’t eat after sundown. And I all the time surprise why would that be. And it seems as a result of it’s essential have three or 4 hours of break after you eat meals earlier than you fall asleep. So, they made that as a faith don’t eat after sundown so as a result of folks will get three, 4 hours of digestion. So, actually telling that, you already know…and that to me was actually the factor that we realized as a part of our tradition. Truly, seems we’re very scientific.
And I wanna come again to the oral merchandise. I feel folks should be actually occupied with oral microbiome well being and utilizing the precise oral toothpaste, oral issues that…you already know, probiotics. And the merchandise, among the merchandise that you’ve, Katie, are designed to reinforce your oral well being and oral microbial actions or oral microbial ecosystem in your mouth. And I feel everybody who’s listening to it to begin listen as a result of that’s the primary. Your mouth really is the start of your digestive tract. It isn’t merely a gap to your digestive tract. It’s the path of the digestive tract the place the digestion occurs.
Katie: I completely agree. I feel very multifaceted however begin with the mouth is so vital. And I really like a few the stuff you simply talked about about why we don’t digest meals if we’re confused and we all know, in fact, that People stay in a persistent state of stress usually. And one factor I’ve turn out to be keen on…you already know, there’s a motive many cultures additionally pray or meditate proper earlier than consuming, which additionally helps the physique get into parasympathetic or you possibly can merely do respiration workouts. Do some field respiration to calm your nervous system. I really like that your loved ones naturally from a non secular perspective stopped consuming at sundown. I’ve realized in my very own life that I do nice once I time restricted eat and for a very long time I’d wait and never eat until midday after which eat later within the day. And I observed once I shifted that to consuming and stopping by sundown, I really feel so a lot better and it goes to that time you talked about about letting your physique end digesting earlier than you sleep in order that once you’re sleeping, you could be therapeutic and your physique can get into autophagy and you’ll allocate sources to all of the pure processes the physique has in-built to maintain us wholesome.
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And I additionally wanna piggyback on what you stated about the identical motive we don’t wanna kill our oral microbiome is similar motive we don’t wanna kill our intestine micro organism as properly however I nonetheless see folks sort of hopping on the bandwagon of those actually harsh cleanses or in fact folks generally take antibiotics for causes whether or not they should or not. And people can each have a reasonably harsh impression on the intestine. And so, I’d love to speak about it. Perhaps if somebody is aware of they’ve been on antibiotics earlier than or they know they’ve a intestine subject associated to actually sort of killing a few of these good micro organism. Clearly, Viome helps with this however sort of, like, what could be achieved? How can we assist repair it?
Naveen: So, very first thing is, you already know, earlier than you go begin taking quite a lot of issues is to know, what’s the state of your intestine micro organism? So do a Viome take a look at, perceive the place it stands. And you then begin to take a look at what you…you already know, we let you know what are the meals you must eat. And once more, taking quite a lot of the fermented meals particularly once you’re making an attempt to repopulate or rebootilate your intestine microbiome, actually the issues needs to be diversification. So as a substitute of simply taking one sort of probiotics, try to be taking kombucha, the kimchi, the…you already know, all of the fermented meals you possibly can probably get your fingers on. So, whether or not it’s a yogurt or, you already know, at the least oat milk yogurt should you can. I imply, I’m a giant fan that I feel dairy…actually for lots of the folks, dairy is the massive downside. Now I’m not saying it’s for everybody however quite a lot of the folks, dairy might be a giant downside. And the mammalian merchandise really might be a giant downside for some folks and never for others.
So, I’m not the one that is preaching veganism right here in any respect. What I’m saying is know what is nice for you. There are lots of people who can eat pink meat for all of their life and stay to be 100, and the rationale for that’s pink meat comprises clearly as you all know, choline and carnitine that may get transformed by our intestine microbiome into issues like TMA. And I discussed TMA is the one which will get absorbed within the blood, causes the TMAO which causes the guts illness. So, it’s not the pink meat that causes the guts illness. It’s the byproduct of how the pink meat is digested in some folks that produce TMA. So, in case your TMA manufacturing is low, you must eat pink meat if you wish to as a result of it’s not gonna hurt you. And that’s actually the purpose is to know, don’t merely ban meals and entire class of meals.
One other factor that we realized…we printed a paper having analyzed over 100,000 folks at the moment on ageing. And what we discovered, Katie, that you could be discover actually fascinating is individuals who have been on these fad diets like, you already know, keto weight-reduction plan or paleo weight-reduction plan have been the worst offender of their organic age. The individuals who have been on keto weight-reduction plan actually have been three to 5 years older than their chronological age and the identical is true for paleo weight-reduction plan. It seems that people who find themselves on balanced weight-reduction plan, which means they have been consuming their carbs however not quite a bit however they have been consuming their regular carbs, they have been consuming their protein, they have been consuming their fats and so they have been consuming the protein, they have been far more balanced, have been really higher off biologically than reducing out the entire nutrient group fully.
Katie: That is sensible, that we’d like the variability. And I’ve realized an increasing number of as properly that I feel the simplistic model all of us realized, hopefully realized at school was about simply sort of energy in, energy out. And I’ve heard it stated, you already know, our physique’s not a checking account. It’s a chemistry lab. And so, I now attempt to eat for maximal micronutrient and nutrient density in meals, not simply hitting or not hitting goal calorie ratios as a result of it’s a lot extra numerous and vital than that.
And what’s subsequent for Viome? I’m curious as a result of I do know you’re consistently doing analysis right here, and such as you stated, your objective is to deal with persistent illness in its entirety. So, what’s within the pipeline for you guys?
Naveen: Truly, I discussed that subsequent take a look at we’re launching in June is a full physique intelligence. We’re launching a most cancers detect take a look at. And we’re making our dietary supplements and probiotics an increasing number of exact for each particular person since we make it for every particular person. We’re, you already know, making an attempt to do extra exams now and our objective is to launch within the subsequent six months one other take a look at which is gonna be extra, like, a proteomics take a look at as a result of the issues we can’t see within the blood as a result of they’re produced some other place. So, can we measure issues, you already know, the proteins for a Hashimoto illness? Can we measure issues like lipopolysaccharide binding protein that may predict if in case you have a leaky intestine by taking a look at LBP, by taking a look at CRP which really is completed within the liver? So, we’re going to have the ability to really measure extra issues along with simply those that we’re measuring, and the extra info we will be taught, the higher suggestions we make. So, our hope is to proceed to launch these exams that give us higher and higher insights and which means we will make an increasing number of exact advice for every particular person.
Final objective actually is to know…as you say, the human physique is a chemistry lab. We’ve got mainly biochemical reactors in our physique. Your physique is a biochemical reactor. And that’s the factor folks want to know that the gene expression tells you what biochemistry is happening within the physique. And that’s a motive…and in reality, Viome is the one firm that does have a look at the gene expression as a result of there isn’t a different firm that has this expertise. And I feel individuals who have listened to your earlier podcast, we talked about, this explicit expertise got here out of Los Alamos Nationwide Lab the place that they had the laboratory for biodefense venture. And that’s the rationale nobody else can do it as a result of it took 10 years and multibillion {dollars}’ price of sources to develop this expertise. Sadly, we have been very lucky to have the ability to get the license to have the ability to use this expertise to assist the humanity get higher. And if our mission was merely to earn cash, we’d not have been capable of license this expertise, proper.
So, the very fact at this time we’re merely targeted on making each single individual be higher. You understand, our mission on day one was what if we might perceive the human biology at a molecular stage so we will stop, diagnose early and treatment these persistent illnesses together with most cancers and ageing? And I feel quite a lot of the individuals who have heard you and I speak prior to now, you already know that I misplaced my dad to most cancers and that was one of many largest motivator for me as a result of if I had began this firm half a decade earlier than I did, I might have probably saved my dad. And, you already know, having watched him undergo that ache or struggling by most cancers I noticed that though I couldn’t save him, I might dedicate my life to saving everybody else. And that shall be my approach of letting him know that, you already know, I’m so pleased with what he…how he raised us as a baby and giving us every thing we’ve so we’re capable of save everybody else’s family members whether or not it’s from coronary heart illness or diabetes or despair, nervousness or most cancers.
And my hope actually is that in our lifetime we are going to completely eradicate most cancers from the human physique. And if I have been to make a prediction at this time, I’ll let you know inside a decade I feel we are going to do away with most cancers from the human physique.
Katie: That’s a giant declare and I hope we’re on monitor for that as properly. I’ve misplaced two prolonged members of the family within the final couple of months alone to most cancers in addition to a few of my grandparents. And it’s no secret that these are all nonetheless very a lot on the rise proper now and I’m certain the persistent stress of the final couple of years isn’t serving to that downside. So, I’m grateful that there are sources such as you, and I’ve achieved Viome. I’m doing an up to date one proper now so I can report again with my outcomes on that. However I additionally am gonna ensure…I do know you’ve provided a reduction code for the Viome testing. In order that hyperlink shall be within the present notes for you guys listening at wellnessmama.fm. You could find the low cost code and the hyperlink on to it there. And to verify I respect your time, there’s a pair final questions I’d like to ask you. The primary being if there’s a ebook or quite a few books which have profoundly influenced your life. And in that case, what they’re and why?
Naveen: Yeah, so the ebook that actually influenced me…there’s a ebook by Clayton Christensen, you already know. I really like the person and I noticed him earlier than he died. The ebook he wrote, “How Will You Measure Your Life?” And to me it was such a profound ebook which tells you that it’s a must to be 100% sincere. You can’t be 99% sincere as a result of as soon as you’re taking a step down of this honesty, it’s a slippery slope and there’s no stopping it. When you make an exception to one thing, there’s simply no going again however there’ll all the time be another excuse to make an exception. And so, it’s a must to focus your self to by no means, ever compromise in your ideas that you just stand for. And that was simply completely a wonderful ebook I learn.
You understand, the ebook that additionally…I imply, clearly I wrote a ebook known as “Moonshots” that’s actually about making a mindset of abundance relatively than a mindset of shortage. And the elemental perception that I’ve is that there’s nothing that people should not able to doing if we really get our mindset to imagine we will. So, any time when somebody says, “I can or I can’t,” it’s true as a result of it’s as much as them to determine whether or not they can or they will’t. That when you imagine one thing is unattainable, it turns into unattainable for you and nobody else. And so, you’re fully in management. The one factor you possibly can’t do is what you possibly can’t think about. Every thing else is feasible.
Katie: I really like that. I do know you and I each increase our youngsters with that mindset and yours are older and doing wonderful issues out on this planet already and mine are to start with levels of that. And lastly, what parting recommendation would you want to go away with the viewers at this time? Might be associated to one thing we’ve talked about or solely unrelated.
Naveen: I’d say dream so huge that individuals assume you’re loopy. Which means by no means let somebody let you know that you would be able to’t do it. Fall in love with your self as a result of the day you fall in love with your self is the day the world will fall in love with you. Loving your self isn’t about being self-conceited. Loving your self is about not searching for another person’s approval to do the issues that imply quite a bit to you. Comply with your coronary heart, comply with your intestine, take heed to your intestine and comply with what it tells you. Discover a goal in life. When you discover a goal in life, you’ll by no means ever assume it’s work. I stand up day-after-day at 4 a.m., and that’s my recommendation to everybody. Everytime you stand up within the morning, should you’re not leaping out of the mattress, you must give up what you’re doing as a result of that’s not your calling, as a result of once you discover your calling, you’ll not be mendacity down within the mattress. You soar out of the mattress with pleasure wanting to unravel that downside.
And, Katie, I simply wish to reiterate, I met your children and I do know I bear in mind the oldest one and I gave him the Moon rock at the moment. I’m telling you your children are going to really transfer this humanity ahead. You might be elevating these kids with the mindset that every thing they wish to do, they will. And each mom who’s listening to it simply ought to know that parenting is definitely very counterintuitive. And, Katie, you and I’ve talked about it quite a lot of instances. Like, once we increase our kids, we inform them, “Our love for you is unconditional however our approval isn’t.” And what which means is solely is that we’ll all the time love you, we’ll all the time be there for you, however I’m not gonna let you know I’m pleased with you except you do issues that make us pleased with you. And that’s actually the factor about telling the kids that their success won’t ever be measured by how a lot cash they’ve within the financial institution. It is going to be measured by what number of lives they enhance. And the humility is an indication of success as a result of should you nonetheless have iota of vanity left in you, which means you’re nonetheless making an attempt to show one thing to your self or another person. And humility tells you now not have to try this, proper. And that could be a true signal of success. And all I can say is I’m so pleased with each considered one of your kids, Katie. And I can’t look ahead to them to develop up and really do issues that can make our kids’s and grandchildren’s life higher.
Katie: Oh, thanks a lot for saying that. Individuals who don’t know, you and I first met and actually bonded over really parenting earlier than we ever talked about well being. And we share that similarity. I inform my children day-after-day, “I really like you unconditionally and there’s nothing you ever should do to earn my love and there’s nothing you possibly can ever do that will take away from my love.” However you’re proper. Additionally, I would like that, like, their pleasure to come back from inside, like…and I inform them usually, “You need to really feel actually pleased with how exhausting you labored and you should…” As a result of I would like them to have that inside them and that self-love.
And because of this I’m so grateful each single day that I get to speak to our viewers that’s listening at this time of mothers, as a result of I feel mothers have such an incredible distinctive potential to actually shift the way forward for humanity by how we guardian our youngsters and by serving to type these future leaders. And for individuals who aren’t already accustomed to you, I’d encourage you to take heed to our previous interview since you inform extra of your story in that one and also you very a lot stroll the stroll of this, of getting constructed all these wonderful issues after which now serving to your children on their life journeys and your spouse in her personal proper is unimaginable as properly. So very grateful to your entire household and for all that each one of you’re doing on this planet and to your time at this time. I understand how busy you’re and I’m so grateful you took the time to be right here.
Naveen: Oh, Katie, it’s all the time an honor and a pleasure to be talking with you, and I’m trying ahead to our subsequent dialog.
Katie: And thanks, as all the time, to all of you for listening and sharing your most beneficial sources, your time, your power, and your consideration with us at this time. We’re each so grateful that you just did. And I hope that you’ll be a part of me once more on the following episode of the “Wellness Mama” podcast.
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